Anti-Opioid δ Receptor antibody produced in rabbit

半岛bd体育手机客户端 说明

一般描述

Opioid peptides are endogenous neuromodulators that play a major role in nociception by interacting with several membrane receptors. Molecular cloning techniques have characterized the nucleotide sequence of several distinct opioid receptors, including the δ-, κ- and μ-opioid receptors.¹The cloned receptors are highly homologous (65%), differing only at the N- and C-termini and at the extracelluar loops that confer binding specificity. All three receptors interact with heterotrimeric G proteins.
δ-Opioid receptors (DOR) are located postsynaptically on pallidostriatal feedback neurons. DORs also modulate nociception presynaptically in the periaqueductal gray where immunolabeling of DOR has been shown to be intracellular and often associated with large dense-core vesicles. Additionally, receptor autoradiographic investigations have localized DORs to the external plexiform layer of the olfactory bulb, the nucleus accumbens, several layers of the cerebral cortex and several nuclei of the amygdala.

References
1. Goldstein, A. Trends Pharmacol. Sci.,8, 456-459 (1987).

特异性

The antiserum is specific for the COOH terminal of the opioid δ receptor.

免疫原

Peptide corresponding to the carboxy-terminal of the opioid δ receptor covalently attached onto a carrier protein.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号	MFCD01633938
NACRES	NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	200
偶联物	unconjugated
抗体形式	whole antiserum
antibody product type	primary antibodies
克隆	polyclonal
形式	lyophilized powder
分子量	antigen ~55 kDa
species reactivity	mouse (predicted), rat
technique(s)	immunocytochemistry: 1:800 using PLP fixed rat brain sections western blot: 1:800 using whole brain homogenate
UniProt登记号	P33533
运输	wet ice
储存温度	?20℃
Gene Information	mouse ... Oprd1(18386) rat ... Oprd1(24613)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)