Anti-Interleukin-12 antibody produced in goat

半岛bd体育手机客户端 说明

一般描述

Interleukin-12 (IL-12) is an important cytokine that links innate and adaptive immunity. It plays a role in the regulation of Th1-associated cellular immunity to foreign pathogens, and humoral immunity to antigens that are both T cell-independent and T cell-dependent. IL-12 is primarily produced by innate immune cells, dendritic cells, epithelial cells and macrophages. All forms of IL-12 bind to the IL-12R which includes IL-12RbI and IL-12RbII subunits expressed on T cells and natural cells. IL-12 stimulates the production of IFN-γ and TNF-α, subsequent production of nitric oxide that leads to pathogen destruction. Reports suggest the involvement of JAK/STAT pathway components in mediating these effects. The effects of IL-12 have been implicated in bacterial, fungal and viral infections. Due to its role in inducing matrix metalloproteases, it also has important role in the etiology of chronic B-cell malignancies and lung adenocarcinomas
Anti-Interleukin-12 antibody recognizes mouse IL-12. It shows < 10% cross-reactivity with recombinant human IL-12 and < 5% cross-reactivity with recombinant porcine IL-12.

特异性

The antibody will neutralize the biological activity of recombinant mouse IL-12. Based on ELISA, the antibody shows ~10% cross-reactivity with recombinant human IL-12 and <5% cross-reactivity with recombinant porcine IL-12.

免疫原

purified, insect cell lineSf21-derived, recombinant mouse IL-12.

应用

Anti-Interleukin-12 antibody may be used for immunoblotting at a working concentration of 1-2 μg/ml. The antibody is also suitable for neutralization reactions. It has been used to neutralize IL-12 in the extracts of murine splenocytes.

外形

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

制备说明

Purified using protein G.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号	MFCD01092387
NACRES	NA.41

半岛bd体育手机客户端 性质

质量水平	100
生物来源	goat
抗体形式	IgG fraction of antiserum
antibody product type	primary antibodies
克隆	polyclonal
species reactivity	mouse
technique(s)	neutralization: suitable western blot: 1-2 μg/mL
UniProt登记号	P43431
储存温度	?20℃
Gene Information	mouse ... Il12a(16159)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable