半岛bd体育手机客户端 说明

一般描述

GABAA and GABAB receptors differ with regard to their ionic characteristics and pharmacological properties. The GABAA receptor is an ionotropic receptor that forms the GABA gated chloride channel and consists of several heterogeneous subunits with membrane recognition sites for benzodiazapenes. GABAA receptor is a ligand-gated chloride channel that is a multimeric subunit complex. So far, around 16 subunits have been identified. This gene encodes the β 2 subunit, which maps to human chromosome 5q34. It is present in a cluster along with genes encoding α 1 and γ 2 subunits of the GABAA receptor.

免疫原

fusion protein of MBP with the amino acid sequence representing the cytosolic loop of the rat GABA_Areceptor (β2 subunit)

应用

Anti-GABAA Receptor (β2 subunit), cytosolic loop antibody produced in rabbit is suitable for western blotting at a working dilution of 1:1000-1:2000 using rat brain membrane. It is also suitable for immunoprecipitation.

生化/生理作用

The inhibitory neurotransmitter GABA signals through two distinct types of pre- and postsynaptic receptors, GABAA and GABAB. Both GABA receptors can regulate depression of synaptic transmission and be involved in the inhibition controlling neuronal excitability. Alterations in N-glycosylation of α1, β1, and β2 have been observed in schizophrenic patients.

外形

Solution in 10 mM HEPES, pH 7.5, 150 mM NaCl, 100 μg/ml BSA and 50% glycerol

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号	MFCD07370323
NACRES	NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	200
偶联物	unconjugated
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
形式	buffered aqueous glycerol solution
用途	sufficient for 10 blots
分子量	antigen 50-53 kDa
species reactivity	rat
technique(s)	immunoprecipitation (IP): suitable western blot: 1:1,000-1:2,000 using rat brain membrane
UniProt登记号	P63138
运输	wet ice
储存温度	?20℃
Gene Information	rat ... Gabrb2(25451)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable