Anti-BID antibody produced in rabbit

半岛bd体育手机客户端 说明

免疫原

synthetic peptide corresponding to N-terminal of cleavage site [59/60] of mouse BID.

应用

Polyclonal anti-BID antibody produced in rabbit is suitable for western blotting by using mouse L929 cells treated with TNF-α. It is also suitable for microarray.

生化/生理作用

The protein encoded by this gene is a member of the BCL-2 family of cell death regulators and is localized on to chromosome 22q11.2. BID is activated by caspase 8 in response to Fas/TNF-R1 receptor activation. Activated BID then translocated to mitochondria where it induces cytochrome c release, which in turn activates downstream caspases. It is a BH3 interacting death domain that heterodimerizes with either agonist BAX or antagonist BCL2. BID initiates apoptosis by binding to regulatory sites on prosurvival BCL2 proteins to directly neutralize their function. Additionally, BID interacts with cathepsins play an important role in the actions of Camptothecin on breast cancer cells.

外形

Supplied as a solution in Dulbecco′s phosphate buffered saline (without Mg²⁺and Ca²⁺), pH 7.3, with 50% glycerol, 1.0 mg/ml BSA (IgG and protease free) and 0.05% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号	MFCD02095892
NACRES	NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	200
偶联物	unconjugated
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
形式	buffered aqueous glycerol solution
分子量	antigen 15 kDa
species reactivity	mouse
technique(s)	microarray: suitable western blot: suitable using mouse L929 cells treated with TNF-α
UniProt登记号	P70444
运输	wet ice
储存温度	?20℃
Gene Information	mouse ... Bid(12122)