Terrein

半岛bd体育手机客户端 说明

生化/生理作用

Terrein is a bioactive fungal metabolite that has plant growth inhibition and antibacterial activities. Terrein reduces melanin levels in a dose-dependent manner as well as tyrosinase protein production.In mammals, there are three melanocyte-specific enzymes: tyrosinase, tyrosinase-related protein-1 (TRP-1), and TRP-2 that are involved in tyrosine conversion into melanin (melanogenesis). Terrein inhibits melanin synthesis by reducing tyrosinase production via extracellular signal-regulated protein kinase (ERK) activation. ERK activation is followed by microphthalmia-associated transcription factor (MITF) down regulation, which is required for tyrosinase expression.

制备说明

Terrein is soluble in water at 1-1.10 mg/ml and yields a clear, colorless solution. It is also soluble in DMSO. Hence, the product may be reconstituted in water or DMSO.

基本信息

经验(实验)分子式	C8H10O3
分子量	154.16
NACRES	NA.77

半岛bd体育手机客户端 性质

生物来源	Aspergillus terreus
质量水平	200
测定	≥98% (HPLC)
储存条件	protect from light
溶解性	H2O: soluble 1-1.10 mg/mL, clear, colorless DMSO: soluble
储存温度	?20℃
InChI	1S/C8H10O3/c1-2-3-5-4-6(9)8(11)7(5)10/h2-4,7-8,10-11H,1H3/b3-2+
InChI key	MHOOPNKRBMHHEC-NSCUHMNNSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable