Spectinomycin

半岛bd体育手机客户端 说明

一般描述

Chemical structure: aminoglycoside

应用

Spectinomycin is an aminocyclitol antibiotic derived fromStreptomyces spectabilis. It has been shown to have a wide variety of uses, including treating acute gonorrheal urethritis and cervictis, to mark cell layers to monitor cell fate during leaf development, as a selection marker in plant related transformation systems for plant cells containing the marker gene Spcr, to study respiratory tract infections of cattle caused byPasteurella multocidaandMannheimia haemolytica,and to generate plants deficient for the plastid-encoded RNA polymerase on MS-agar media. Spectinomycin also has use in amplification of low copy number plasmid carrying replicons. It is recommended for use in cell culture applications at 7.5-20 mg/L.

包装

1 mL in glass bottle

生化/生理作用

作用方式：通过干扰肽基 tRNA 的转位抑制蛋白质合成(延伸)。
抗菌谱：革兰氏阴性和革兰氏阳性菌(仅包括淋球菌)。
抗性机理：rpsE(核糖体蛋白 S5 的基因)的突变可阻止壮观霉素的结合。

注意

Solutions can be stored at 2-8℃ for several weeks or at -20℃ for more extended periods.

制备说明

Stock solutions should be prepared at 10 mg/mL in water and 0.2 μm filtered.

其他说明

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Store under inert gas

基本信息

MDL编号	MFCD04041129
NACRES	NA.85

半岛bd体育手机客户端 性质

质量水平	200
生物来源	Streptomycessp.
形式	solution
储存条件	(Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.Store under inert gas.)
浓度	100 mg/mL in DMSO/H2O, 1:1
颜色	colorless
溶解性	DMSO/H2O, 1:1: soluble 100 mg/mL
作用机制	protein synthesis | interferes
抗生素抗菌谱	Gram-negative bacteria Gram-positive bacteria mycobacteria
运输	wet ice
储存温度	?20℃

安全信息

储存分类代码	10 - Combustible liquids
WGK	WGK 2
闪点(F)	201.0 °F - closed cup
闪点(C)	93.9 ℃ - closed cup
个人防护装备	Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)