Purvalanol A-CAS 212844-53-6-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A potent, cell-permeable, reversible, and selective inhibitor of cyclin-dependent kinases (Cdks; IC₅₀= 4 nM for Cdc2-cyclin B; IC₅₀= 70 nM for Cdk2-cyclin A; IC₅₀= 35 nM for Cdk2-cyclin E; and IC₅₀= 75 nM for Cdk5-p35).
A potent, cell-permeable, reversible, and selective inhibitor of cyclin-dependent kinases (Cdks; IC₅₀= 4 nM for Cdc2/cyclin B; IC₅₀= 70 nM for Cdk2/cyclin A; IC₅₀= 35 nM for Cdk2/cyclin E; and IC₅₀= 75 nM for Cdk5/p35).

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Product does not compete with ATP.
Primary Target
Cdc2/cyclin B
Reversible: yes
Cell permeable: yes
Target IC₅₀: 4 nM for Cdc2/cyclin B; 70 nM for Cdk2/cyclin A; 35 nM for Cdk2/cyclin E; 75 nM for Cdk5/p35

警告

Toxicity: Standard Handling (A)

重悬

Following initial thaw, aliquot and freeze (-20°C).

其他说明

Gray, N.S., et al. 1998.Science281,533.

法律信息

Sold under license of U.S. Patents 6,617,331 and 6,803,371.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C19H25ClN6O
分子量	388.89
MDL编号	MFCD02179211

半岛bd体育手机客户端 性质

质量水平	100
测定	≥97% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze
颜色	off-white
溶解性	DMSO: 100 mg/mL
运输	ambient
储存温度	?20℃
InChI	1S/C19H25ClN6O/c1-11(2)15(9-27)23-19-24-17(22-14-7-5-6-13(20)8-14)16-18(25-19)26(10-21-16)12(3)4/h5-8,10-12,15,27H,9H2,1-4H3,(H2,22,23,24,25)/t15-/m0/s1
InChI key	PMXCMJLOPOFPBT-HNNXBMFYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3