半岛bd体育手机客户端 说明

一般描述

Protein C from human plasma is encoded by the gene PROC. In human chromosome, the gene is localised on chromosome 2q14. Activated protein C (APC) cleaves protease activated receptor 1 (PAR1) resulting in cytoprotective and anti-inflammatory effects. Clinical trials with APC implicates its use in treating severe early onset preeclampsia in pregnant women and prolongs pregnancy and helps in perinatal outcomes.

应用

Protein C from human plasma has been used for pre-treatment of endothelial cells prior to antibody-inhibition assay. It has also been used in activated protein C (APC) assay to determine its inhibitory effect on copper.

生化/生理作用

Protein C is a plasma, vitamin κ-dependent zymogen of a serine protease that can inhibit blood coagulation by inhibiting thrombin formation, selectively inactivating Factors Va and VIIIa.
In addition, activated protein C has been shown to inhibit TNF-α induced expression of the inflammatory proteins VCAM, ICAM-I, and Ilk-8 in endothelial cells.
Protein C is a plasma, vitamin κ-dependent zymogen of a serine protease that can inhibit blood coagulation by inhibiting thrombin formation, selectively inactivating Factors Va and VIIIa. The Protein C anticoagulant pathway is triggered when thrombin binds to the endothelial cell proteoglycan, thrombomodulin. This complex, which cannot clot blood, is a potent activator of the protein C zymogen. Activation involves the release of a dodecapeptide from the N-terminal domain of the heavy chain. The activated Protein C (APC) then binds to protein S on cell surfaces and inactivates the coagulation factors Va and VIIIa by proteolysis. APC has also been shown to bind to receptors on the endothelium of large blood vessels.

外形

Lyophilized powder from 20 mM Tris-HCl, pH 7.4, containing 0.1 M NaCl

基本信息

酶学委员会(EC)编号	3.4.21.69 ( BRENDA | IUBMB )
MDL编号	MFCD00165567
NACRES	NA.61

半岛bd体育手机客户端 性质

质量水平	200
生物来源	human plasma
测定	≥90% (SDS-PAGE)
形式	lyophilized powder
分子量	heavy chain 41 kDa light chain 21 kDa
technique(s)	inhibition assay: suitable
溶解性	H2O: 1 mg/mL
UniProt登记号	P04070
储存温度	?20℃
Gene Information	human ... PROC(5624)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable