半岛bd体育手机客户端 说明
一般描述
A potent, cell-permeable, reversible, competitive, and selective p38 MAP kinase inhibitor (IC50= 89 nM). Inhibition of p38 MAP kinase by PD 169316 blocks apoptosis induced by trophic factor withdrawal in non-neuronal and neuronal cell lines.
A potent, cell-permeable, reversible, competitive, and selective p38 MAP kinase inhibitor (IC50= 89 nM). Inhibition of p38 MAP kinase by PD 169316 blocks apoptosis induced by trophic factor withdrawal in non-neuronal and neuronal cell lines.
包装
1 mg in Plastic ampoule
生化/生理作用
Cell permeable: yes
Product competes with ATP.
Primary Target
p38 MAP kinase
Reversible: yes
Target IC50: 89 nM against p38 MAP kinase
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
其他说明
Nath, R., et al. 2001.Cell Mol. Biol. Lett.6,173.
Gallagher, T.F., et al. 1997.Bioorg. Med. Chem.5,49.
Kummer, J.L., et al. 1997.J. Biol. Chem.272,20490.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
经验(实验)分子式 | C20H13FN4O2 |
分子量 | 360.34 |
MDL编号 | MFCD12405019 |
半岛bd体育手机客户端 性质
质量水平 | 100 |
测定 | ≥98% (HPLC) |
形式 | solid |
manufacturer/tradename | Calbiochem? |
储存条件 | OK to freeze protect from light |
颜色 | orange-yellow |
溶解性 | DMSO: 10 mg/mL |
运输 | ambient |
储存温度 | ?20℃ |
安全信息
象形图 | |
警示用语: | Danger |
危险声明 | H301 - H315 - H318 - H335 |
预防措施声明 | P261 - P264 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338 |
危险分类 | Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3 |
靶器官 | Respiratory system |
储存分类代码 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich