Monoclonal Anti-S1P₂, C-Terminal antibody produced in mouse

半岛bd体育手机客户端 说明

免疫原

human EDG-5/S1P₂unique C-terminal peptide.

应用

Monoclonal Anti-S1P₂, C-Terminal antibody produced in mouse is suitable for western blotting at a working dilution of 1:1000 (1μg/mL) using human T lymphoblasts, ovarian tumor cells, epithelial cells, estrogen receptor positive breast carcinoma cells, human spleen and rat spleen or lung.

生化/生理作用

Sphingosine-1-phosphate receptor 2 (S1PR2 or S1P2) is a human gene encodes a G protein-coupled receptor. It binds the lipid signaling molecule sphingosine 1-phosphate (S1P) and regulates vascular permeability along with S1P1. Activation of S1P2R in endothelial cells increases vascular permeability. It is a bioactive lysophospholipid capable of inducing a wide spectrum of biological responses. S1P acts as an intercellular mediator by interacting with the endothelial differentiation gene (EDG)/S1P family of G protein-coupled receptors. S1P2 receptor is involved in S1P-induced platelet aggregation and Rho kinase activation. Type 2 diabetes patient responds to S1P.

目标描述

EDG-5/S1P₂belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG-5/S1P₂is sphingosine 1-phosphate, and is expressed in cardiovascular, central nervous system, gonadal, placental and leukocyte-containing tissue.

制备说明

Purified fromin vitrocell culture supernatants using protein A.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号	MFCD02686109
NACRES	NA.41

半岛bd体育手机客户端 性质

质量水平	200
生物来源	mouse
偶联物	unconjugated
抗体形式	purified immunoglobulin
antibody product type	primary antibodies
克隆	AS65, monoclonal
形式	buffered aqueous solution
分子量	antigen ~45 kDa
species reactivity	human, rat
technique(s)	western blot: suitable
同位素/亚型	IgG
UniProt登记号	O95136
运输	dry ice
储存温度	?20℃
Gene Information	human ... S1PR2(9294) rat ... S1pr2(29415)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable