Monoclonal Anti-Granzyme B antibody produced in mouse

半岛bd体育手机客户端 说明

特异性

Does not cross-react with granzyme A.

免疫原

recombinant human granzyme B.

应用

Monoclonal Anti-Granzyme B antibody is suitable for western blot and immunocytochemistry at a dilution of 1:20 using pretreated tissues.

生化/生理作用

Granzyme B, neutral serine protease, is expressed in cytoplasmic granules of activated cytotoxic T lymphocytes and natural killer cells. It contains a leader sequence (cleaved by a signal peptidase) and two amino acid prodomains (cleaved by the lysosomal cysteine protease DPPI). It plays a major role in the caspase dependent apoptotic pathway by activating most of the caspasesin vitroandin vivo. It cleaves the aspartic acid residues, to facilitate cell death by various pathways. It has been shown that granzyme B has capacity to facilitate cytochrome C release from the mitochondria in a caspase independent way.

外形

Supplied in serum-free culture medium containing 1% bovine serum albumin and 0.1% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号	MFCD01865484
NACRES	NA.41

半岛bd体育手机客户端 性质

质量水平	200
生物来源	mouse
偶联物	unconjugated
抗体形式	tissue culture supernatant
antibody product type	primary antibodies
克隆	GrB7, monoclonal
描述	not suitable for immunocytochemistry (frozen sections)
分子量	antigen 33 kDa
species reactivity	human
technique(s)	immunocytochemistry: 1:20 using pretreated tissues western blot: suitable
UniProt登记号	P10144
运输	dry ice
储存温度	?20℃
Gene Information	human ... GZMB(3002)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable