Damnacanthal-CAS 477-84-9-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A cell-permeable, potent, reversible, and selective inhibitor of p56^lcktyrosine kinase activity. Inhibits p56^lckautophosphorylation (IC₅₀= 17 nM) and phosphorylation of an exogenous peptide by p56^lckover PKA and PKC and >40 fold selectivity for p56^lckover EGF, c-erbB2, insulin, and the PDGF receptor tyrosine kinases. In addition, damnacanthal exhibits 7-20 fold selectivity for p56^lckover pp60^srcand pp59^fyn. Inhibition of p56^lckby damnacanthal appears to be reversible, not time-dependent and not significantly affected by the presence of sulfhydryl reagents. Also known to have antimalarial properties, and to reverse the phenotype ofras-transformed cells.
A cell-permeable, potent, reversible, and selective inhibitor of p56^lcktyrosine kinase. Inhibits p56^lckautophosphorylation (IC₅₀= 17 nM) and phosphorylation of an exogenous peptide by p56^lck(IC₅₀= 620 nM). Exhibits over 100-fold greater selectivity for p56^lckover PKA and PKC, 40-fold greater selectivity for p56^lckover EGF receptor kinase, c-ErbB2, insulin receptor kinase, and PDGF receptor kinase, and 7 - 20-fold greater selectivity for p56^lckover p60^srcand p59^fyn. Inhibition of p56^lckis not significantly affected by the presence of sulfhydryl reagents. Also known to have antimalarial properties and to reverse the phenotype ofras-transformed cells.

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
p56^lckautophosphorylation
Target IC₅₀: 17 nM against p56lck autophosphorylation
Product does not compete with ATP.
Reversible: yes

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

其他说明

Faltynek, C.R., et al. 1995.Biochemistry34,12404.
Hiramatsu, T., et al. 1993.Cancer Lett.73,161.
Koumaglo, K., et al. 1992.Planta Med.58,533.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C16H10O5
分子量	282.25

半岛bd体育手机客户端 性质

质量水平	100
测定	≥95% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze protect from light
颜色	orange-yellow
溶解性	DMSO: 5 mg/mL
运输	ambient
储存温度	?20℃
InChI	1S/C16H10O5/c1-21-16-11(7-17)12(18)6-10-13(16)15(20)9-5-3-2-4-8(9)14(10)19/h2-7,18H,1H3
InChI key	IPDMWUNUULAXLU-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 1