半岛bd体育手机客户端 说明
一般描述
A cell-permeable, potent, reversible, and selective inhibitor of p56lcktyrosine kinase activity. Inhibits p56lckautophosphorylation (IC50= 17 nM) and phosphorylation of an exogenous peptide by p56lckover PKA and PKC and >40 fold selectivity for p56lckover EGF, c-erbB2, insulin, and the PDGF receptor tyrosine kinases. In addition, damnacanthal exhibits 7-20 fold selectivity for p56lckover pp60srcand pp59fyn. Inhibition of p56lckby damnacanthal appears to be reversible, not time-dependent and not significantly affected by the presence of sulfhydryl reagents. Also known to have antimalarial properties, and to reverse the phenotype ofras-transformed cells.
A cell-permeable, potent, reversible, and selective inhibitor of p56lcktyrosine kinase. Inhibits p56lckautophosphorylation (IC50= 17 nM) and phosphorylation of an exogenous peptide by p56lck(IC50= 620 nM). Exhibits over 100-fold greater selectivity for p56lckover PKA and PKC, 40-fold greater selectivity for p56lckover EGF receptor kinase, c-ErbB2, insulin receptor kinase, and PDGF receptor kinase, and 7 - 20-fold greater selectivity for p56lckover p60srcand p59fyn. Inhibition of p56lckis not significantly affected by the presence of sulfhydryl reagents. Also known to have antimalarial properties and to reverse the phenotype ofras-transformed cells.
包装
1 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Cell permeable: yes
Primary Target
p56lckautophosphorylation
Target IC50: 17 nM against p56lck autophosphorylation
Product does not compete with ATP.
Reversible: yes
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
其他说明
Faltynek, C.R., et al. 1995.Biochemistry34,12404.
Hiramatsu, T., et al. 1993.Cancer Lett.73,161.
Koumaglo, K., et al. 1992.Planta Med.58,533.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
经验(实验)分子式 | C16H10O5 |
分子量 | 282.25 |
半岛bd体育手机客户端 性质
质量水平 | 100 |
测定 | ≥95% (HPLC) |
形式 | solid |
manufacturer/tradename | Calbiochem? |
储存条件 | OK to freeze protect from light |
颜色 | orange-yellow |
溶解性 | DMSO: 5 mg/mL |
运输 | ambient |
储存温度 | ?20℃ |
InChI | 1S/C16H10O5/c1-21-16-11(7-17)12(18)6-10-13(16)15(20)9-5-3-2-4-8(9)14(10)19/h2-7,18H,1H3 |
InChI key | IPDMWUNUULAXLU-UHFFFAOYSA-N |
安全信息
储存分类代码 | 11 - Combustible Solids |
WGK | WGK 1 |
Sigma-Aldrich