半岛bd体育手机客户端 说明

生化/生理作用

The complement system is a complex cascade involving proteolytic cleavage of serum glycoproteins often activated by cell receptors. This cascade ultimately results in induction of the inflammatory response, phagocyte chemotaxis and opsonization, and cell lysis.
A complex of complements C5b, C6, C7, and C8 mediates the polymerization of up to eighteen C9 molecules into a tube-like membrane attack complex that is inserted into the plasma membrane of unwanted organisms, such as of Gram-negative bacteria and viral infected cells. This channel through the lipid bilayer results in lysis of the cell.
Human Complement C7 is a β-2-globulin, which is composed of a single polypeptide chain. The initial binding of C7 and C6 to C5b is thought to form a stable complex for subsequent binding of C8 and C9. The resulting activated complex is responsible for membrane attack and lysis.

质量

Functionally active by a sensitive hemolytic assay.

基本信息

MDL编号	MFCD00130845
NACRES	NA.75

半岛bd体育手机客户端 性质

质量水平	200
生物来源	human serum
测定	≥85% (SDS-PAGE)
形式	solution
specific activity	≥150,000 C7H50 units/mg protein
浓度	1 mg/mL in 10 mM sodium phosphate, 150 mM sodium chloride, pH 7.2
technique(s)	activity assay: suitable
UniProt登记号	P10643
运输	dry ice
储存温度	?70℃
Gene Information	human ... C7(730)

安全信息

储存分类代码	12 - Non Combustible Liquids
闪点(F)	Not applicable
闪点(C)	Not applicable