Aphidicolin, Ready Made Solution

半岛bd体育手机客户端 说明

一般描述

Aphidicolin is a tetracyclic diterpene with antiviral and antimitotic properties used for cell cycle synchronization in various cell lines.

应用

Aphidicolin, fromNigrospora sphaerica, was used for cell cycle synchronization of tobacco BY-2 cells. It is used to block the entry of cells into S-phase.

生化/生理作用

Aphidicolin specifically inhibits DNA polymerase α that is responsible for DNA replication. It also inhibits α-like DNA polymerases of plants and yeasts but does not inhibit synthesis of RNA and proteins. Aphidicolin competes for the dCTP-specific binding site on DNA polymerase α specifically. Aphidicolin has antiviral and antimitotic properties. It blocks the cell cycle at S phase. It has been shown to induce apoptosis in HeLa cells.

包装

1 ml

外形

Aphidicolin Ready Made Solution supplied as a 1 mg/ml solution in DMSO.

其他说明

Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Combustible liquids

基本信息

经验(实验)分子式	C20H34O4
分子量	338.48
EC 号	200-664-3
MDL编号	MFCD00083214
NACRES	NA.85

半岛bd体育手机客户端 性质

生物来源	Nigrospora sphaerica
质量水平	200
蒸汽压	0.55 hPa ( 20 ℃)
形式	liquid
颜色	clear colorless
溶解性	H2O: miscible (completely)
作用机制	DNA synthesis | interferes enzyme | inhibits
抗生素抗菌谱	neoplastics viruses
储存温度	?20℃
InChI	1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1
InChI key	NOFOAYPPHIUXJR-APNQCZIXSA-N

安全信息

储存分类代码	10 - Combustible liquids
WGK	WGK 1
闪点(F)	188.6 °F - closed cup
闪点(C)	87 ℃ - closed cup