Anti-Stem Cell Factor antibody produced in goat

半岛bd体育手机客户端 说明

一般描述

Mast cells play an important role in innate immunity or the response of the body to invading pathogens. The functions of mast cells are regulated by a number of surface receptors; the receptors to Stem cell factor (SCF; c-Kit ligand or mast cell growth factor) being the most critical. The signalling triggered by SCF results in mast cell activation in response to antigens. The response involves tyrosine phosphorylation by specific tyrosine kinases that drive the downstream signalling process. The secondary pathways activated by SCF are signalling mediated by Akt, mTOR, MAPK and c-Jun. In addition to development of mast cells, SCF also regulates their subsequent maturation and homing to the residence sites. Constitutive activation by SCF is implicated in myeloproliferative discorders, systemic mastocytosis and gastrointestinal stomal cell tumors
Anti-Stem Cell Factor antibody reacts specifically with mouse stem cell factor.

特异性

The antibody will neutralize the biological activity of recombinant mouse SCF.

免疫原

recombinant mouse SCF

应用

Anti-Stem Cell Factor antibody may be used to neutralize SCF at a concentration of 25 ng/ml in 1X10⁵/ml TF-1 cells. The antibody has been used to neutralize SCF in primary murine embryonic fibroblast (MEF) culture. The recommended concentration for indirect ELISA is 1.0 μg/ml and for immunoblotting is 2.0 μg/ml.

包装

1 mg in glass bottle

外形

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline

制备说明

Purified using protein G

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号	MFCD01865052
NACRES	NA.41

半岛bd体育手机客户端 性质

质量水平	100
生物来源	goat
偶联物	unconjugated
抗体形式	IgG fraction of antiserum
antibody product type	primary antibodies
克隆	polyclonal
形式	lyophilized powder
species reactivity	mouse
technique(s)	neutralization: suitable
储存温度	?20℃
Gene Information	mouse ... Kitl(17311)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)