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位置: 首页> 品牌> Sigma-Aldrich> Anti-phospho-PAK1/2/3 (pThr423) antibody produced in rabbit

Anti-phospho-PAK1/2/3 (pThr423) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
P7746
规格纯度
affinity isolated antibody, buffered aqueous glycerol solution
价格
9341.66 *本价格含增值税费
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半岛bd体育手机客户端 名称:
Anti-phospho-PAK1/2/3 (pThr 423) antibody produced in rabbit
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

p21-activated kinases are a family of highly conserved serine/threonine protein kinases that are activated by small GTPases of Cdc42 and Rac families. There are 2 groups of PAKs in mammals, group A and B. The group A members are three isoforms, PAK1, PAK2, and PAK3 (also known as α-PAK, γ-PAK, and β-PAK, respectively). PAKs are actively involved in regulation of MAPK pathways by phosphorylation of Raf-1 and MEK-1. They also regulate cytoskeletal reorganization by interaction with GTPases. Autophosphorylation of threonine 423 (threonine 402 for PAK2 and threonine 421 for PAK3), catalyzed by Cdc42, is required for activation of PAK.
The antibody detects human PAK1, PAK2 and PAK3, phosphorylated at Thr423. Other species with 100% PAK homology are expected to react.

免疫原

synthetic phosphopeptide derived from the region of PAK that contains threonine 423.

应用

A recommended working concentration of 0.1-1.0 μg/mL is determined by immunoblotting using Histagged wild-type and S139A/T421A double mutant PAK3.

外形

Solution in Dulbecco′s phosphate buffered saline (without Mg2+and Ca2+), pH 7.3, with 50% glycerol, 1.0 mg/mL BSA (IgG and protease free) and 0.05% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号 MFCD06411891
NACRES NA.44

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 200
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous glycerol solution
species reactivity human
technique(s) western blot: 1:1,000 using His-tagged wild-type and S139A/T421A double mutant PAK3.
UniProt登记号 Q13153
运输 wet ice
储存温度 ?20℃
Gene Information human ... PAK1(5058)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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