Anti-phospho-p53 (pSer³⁹²) antibody produced in rabbit

半岛bd体育手机客户端 说明

一般描述

p53 is a tumor suppressor gene expressed in a wide variety of tissues. It is a tetrameric nuclear DNA-binding phosphoprotein. The gene encoding it is localized on human chromosome 17p13.1 and mouse chromosome 11.

特异性

Does not react with non-phosphorylated p53.

免疫原

synthetic peptide corresponding to residues around Ser³⁹²of human p53 conjugated to KLH.

生化/生理作用

Tumor suppressor p53 has the capability to induce cell cycle arrest and has a role in DNA repair, senescence and apoptosis. It binds to Simian vacuolating virus 40 (SV40) T-antigen and human papilloma virus E6 protein. The p53 gene is mutated in various cancers, such as of the breast, ovarian, bladder, colon and lung.

外形

Solution in 10 mM sodium HEPES, pH 7.5, containing 150 mM sodium chloride, 100 μg/ml bovine serum albumin and 50% glycerol

制备说明

Purified using protein A and peptide affinity chromatography.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号	MFCD02097164
NACRES	NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	200
偶联物	unconjugated
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
形式	buffered aqueous glycerol solution
分子量	antigen 53 kDa
species reactivity	mouse, human
technique(s)	microarray: suitable western blot (chemiluminescent): 1:1,000 using p53 fusion proteins with CKII phosphorylation or an extract of hydroxyurea-treated MvILu cells
UniProt登记号	P04637
运输	wet ice
储存温度	?20℃
Gene Information	human ... TP53(7157) mouse ... Trp53(22059)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable