Anti-phospho-MEK4 (pSer²⁵⁷/pThr²⁶¹) antibody produced in rabbit

半岛bd体育手机客户端 说明

一般描述

Mitogen-Activated Protein Kinase Kinase 4 (MEK 4 or MKK4) is a 42 kDa member of a tyrosine/threonine protein kinase family that activates the c-Jun NH2-terminal kinases (JNK), which is part of the inflammation/stress signaling pathway. The mutation of the MEK 4 gene in some carcinomas indicates that it may also have a role as a tumor suppressor. Phosphorylation of MEK4 by MEKK1 on serine 257 and threonine 261 in the catalytic domain activates the protein and enables MEK 4 to phosphorylate JNK
This antibody specifically recognizes human MEK 4 double phosphorylated at serine 257 and threonine 261. Mouse and frog MEK 4 (100% homology) may cross react.

免疫原

synthetic MEK4-derived phosphopeptide that is phosphorylated at serine 257 and threonine 261.

应用

Anti-phospho-MEK4 (Tyr³⁹⁷) antibody may be used for detection by immunoblotting at a working concentration of 0.1-1.0 μg/mL.

外形

Solution in Dulbecco′s phosphate buffered saline (without Mg²⁺and Ca²⁺), pH 7.3, with 1.0 mg/mL BSA (IgG and protease free) and 0.05% sodium azide.

基本信息

MDL编号	MFCD06798497
NACRES	NA.44

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	200
偶联物	unconjugated
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
形式	buffered aqueous solution
species reactivity	frog, mouse, human
technique(s)	western blot: 0.1-1.0 μg/mL using extracts prepared from GST-tagged fusion protein expressing MEK 4.
UniProt登记号	P45985
运输	dry ice
储存温度	?70℃
Gene Information	human ... MAP2K4(6416) mouse ... Map2k4(26398)