Anti-phospho-Insulin Receptor (IR) (pTyr⁹⁷²) antibody produced in rabbit

半岛bd体育手机客户端 说明

一般描述

The biological effects of insulin are mediated by insulin receptor (IR) and IGF-1 receptor. Insulin receptor consists of two α and two β subunits, each subunit has a tyrosine kinase domain. Signaling by IR is important in cell proliferation and metabolism of glucose. Insulin receptor activates the PI3K/Akt and the FKHR pathway, thereby regulates metabolism and insulin-dependent gene expression. Tyrosine 972 is an autophosphorylation site that is present in the juxtamembrane domain. Phosphorylation at Tyr972 is required for interaction of IR with its intracellular substrates and increases the stability of IR and substrate complexes. Overexpression of IR has been observed in breast cancer tissue and is implicated in proliferation of breast cancer cells, hyperinsulinemia and insulin resistance. IR can also bind IGF-I and IGF-II with decreased affinity
Anti-phospho-IR (pTyr⁹⁷²) recognizes human and mouse IR phosphorylated on tyrosine 972. It may cross react with IGF-1R.

特异性

This antibody may also have cross-reactivity with phosphosphorylated insulin-like growth factor-1 receptor (IGF-1R).

免疫原

phosphopeptide derived from the region of human insulin receptor (IR) that contains tyrosine 972.

外形

Solution in Dulbecco′s phosphate buffered saline (without Mg²⁺and Ca²⁺), pH 7.3, 50% glycerol with 1 mg/ml of bovine serum albumin and 0.05% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号	MFCD05665246
NACRES	NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	200
偶联物	unconjugated
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
形式	buffered aqueous solution
species reactivity	mouse, human
UniProt登记号	P14616
运输	dry ice
储存温度	?70℃
Gene Information	human ... INSRR(3645) mouse ... Insr(16337)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)