您好,欢迎来到半岛电竞官方网址 ! [ 登录] [ 免费注册]
半岛电竞官方网址
位置: 首页> 品牌> Sigma-Aldrich> Anti-phospho-Epidermal Growth Factor Receptor [pTyr1148] antibody produced in rabbit

Anti-phospho-Epidermal Growth Factor Receptor [pTyr1148] antibody produced in rabbit

品牌
Sigma-Aldrich
货号
E1655
规格纯度
affinity isolated antibody, buffered aqueous glycerol solution
价格
4330.86 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
Anti-phospho-Epidermal Growth Factor Receptor [pTyr 1148] antibody produced in rabbit
Anti-phospho-EGFR [pTyr 1148]
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The members of epidermal growth factor receptor (EGF R) or the ErbB receptor family have been identified as useful biomarkers and targets for cancer therapy. The EGFR family includes four receptor tyrosine kinases, EGF R (ErbB1), ErbB2 (neu), ErbB3, and ErbB4. EGF R binds EGF and induces tyrosine phosphorylation leading to proliferation of cells. EGF R is present on many cell types of epithelial and mesenchymal lineages. EGF R is capable of binding transforming growth factor-α and heparin-binding EGF in addition to EGF. There are numerous effector molecule activated by EGF R that result in a variety of biological processes such as morphogenesis, cell motility, apoptosis, differentiation and organ repair and maintenance. Deregulation of EGF R signaling is implicated in progression of a wide variety of tumors, invasion and metastasis. Phosphorylation of EGF R at Tyr1148 is by autophosphorylation may be required for the binding of protein tyrosine phosphatase, SHP-1, which results in dephosphorylation of EFG R
Anti-phospho-EGFR [pTyr1148] specifically recognizes human EGFR phosphorylated at tyrosine 1148.

免疫原

synthetic phosphopeptide derived from the region of EGFR that contains tyrosine 1148.

应用

Anti-phospho-EGFR [pTyr1148] antibody may be used at a working dilution of 1:1000 for immunoblotting using A431 cells stimulated with EGF.

外形

Solution in Dulbecco′s phosphate buffered saline (without Mg2+and Ca2+), pH 7.3, with 50% glycerol, 1.0 mg/mL BSA (IgG, protease free) as a carrier and 0.05% sodium azide.

基本信息

MDL编号 MFCD03845327
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 200
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous glycerol solution
分子量 antigen ~170 kDa
species reactivity human
technique(s) western blot: 1:1,000 using human epithelial A431 cells stimulated with EGF or mouse hybridoma NIH3T3 cells expressing human EGFR and stimulated with EGF
UniProt登记号 P00533
运输 wet ice
储存温度 ?20℃
Gene Information human ... EGFR(1956)

Sigma-Aldrich

推荐半岛bd体育手机客户端
Baidu
map