Anti-phospho-DARPP32 (pThr³⁴) antibody produced in rabbit

半岛bd体育手机客户端 说明

一般描述

DARPP32 is a phosphoprotein with a molecular mass of 32kDa. It is regulated by dopamine (DA) and cAMP and is associated with dopaminoceptive neurons bearing D-1 receptors in the basal ganglia. DARPP32 is a target for the actions of dopamine.

免疫原

synthetic phosphopeptide corresponding to amino acids residues surrounding the DARPP32 phosphorylated on threonine 34

生化/生理作用

Dopamine D1 receptor stimulation enhances cAMP formation, resulting in the phosphorylation of DARPP32. When phosphorylated on threonine 34, DARPP32 acts as a potent protein phosphatase- inhibitor. This phosphorylation plays an important role in the regulation of dopaminergic neurotransmission. The activity of this protein has an important role in the actions of alcohol, caffeine and Prozac^?.

目标描述

DARPP32 phosphorylated on Thr⁷⁵acts as an inhibitor of PKA.

外形

Solution at 100 μL in 10 mM HEPES, pH 7.5, 150 mM NaCl, 100 μg/mL BSA, and 50% glycerol.

法律信息

Prozac is a registered trademark of Eli Lilly and Co.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号

MFCD08705495

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	200
偶联物	unconjugated
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
形式	buffered aqueous glycerol solution
用途	sufficient for 10 blots
分子量	~32 kDa
species reactivity	rat, mouse
technique(s)	western blot: 1:1,000 using rat caudate lysates
UniProt登记号	Q6J4I0
运输	wet ice
储存温度	?20℃
Gene Information	human ... PPP1R1B(84152) mouse ... Ppp1r1b(19049) rat ... Ppp1r1b(360616)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)