Anti-Interleukin-1α antibody produced in goat

半岛bd体育手机客户端 说明

一般描述

Interleukins are proinflammatory cytokines produced on cell injury or trauma. There are two closely related types of interleukins produced by the cell, IL-1α and IL-1β that are produced by the activation of NF-κ B transcription factor in response to bacterial infection or LPS. Both IL-1α and IL-1β exert their cellular effects by signalling through IL-1 receptor type 1. A variety of cells such as macrophages, epithelial cells, fibroblasts, keratinocytes, monocytes and dendritic cells secrete IL-1α. Both IL-1α and IL-1β are important in acquired immunity, inflammation, response to infection and production of matrix metalloproteinases (MMPs). The effects of IL-1α are mediated by activation of NF-κB, JNK and MAPK pathways that activated the genes in response to infection and inflammation. Overproduction of IL-1α has been implicated in inflammatory disorders like rheumatoid arthritis and periodontitis
Anti-interleukin-1α specifically reacts with human IL-1α. It does not react with human IL-1β and mouse IL-1β or mouse IL-1α in neutralization reactions. It shows 5% cross reactivity with mouse IL-1α in immunoblotting applications.

免疫原

purified,E. coli-derived recombinant human interleukin-1α.

应用

Anti-interleukin 1α antibody may be used for immunoblotting at a working concentration of 1-2 μg/ml. It is also suitable for neutralization reactions.

外形

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

基本信息

MDL编号	MFCD00165461
NACRES	NA.41

半岛bd体育手机客户端 性质

质量水平	100
生物来源	goat
偶联物	unconjugated
抗体形式	IgG fraction of antiserum
antibody product type	primary antibodies
克隆	polyclonal
形式	lyophilized powder
species reactivity	human
technique(s)	neutralization: suitable western blot: 1-2 μg/mL
UniProt登记号	P01583
储存温度	?20℃
Gene Information	human ... IL1A(3552)