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Anti-DFF45, N-Terminal antibody produced in rabbit

品牌
Sigma-Aldrich
货号
D3438
规格纯度
IgG fraction of antiserum, buffered aqueous solution
价格
4330.86 *本价格含增值税费
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半岛bd体育手机客户端 名称:
Anti-DFF45, N-Terminal antibody produced in rabbit
Anti-ICAD
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

DFF exists as an inactive cytoplasmic protein until activated by apoptotic signals. DFF40, the nuclease responsible for DNA fragmentation during apoptosis, exists as a heterodimeric complex with DFF45.

免疫原

synthetic peptide corresponding to amino acids 2-21 of the N-terminal region of human DFF45/ICAD (DNA Fragmentation Factor 45/Inhibitor of Caspase-3 Activated DNase I).

应用

Anti-DFF45 antibody produced in rabbit is suitable for immunoblotting at a working concentration of 0.5μg/mL using a total HeLa cell lysate.

生化/生理作用

DFF45 functions as both a chaperone, mediating the correct folding of DFF40, and an inhibitor of DFF40. DFF45 is cleaved by caspase-3 at two sites in response to apoptotic signals. This releases DFF40, the active nuclease. DFF40 seems to oligomerize, forming a large, functional complex which breaks down DNA by introducing double strand breaks. Also, DFF40 appears to interact directly with histone H1 that may stimulate its activity.

外形

Solution in phosphate buffered saline containing 0.02% sodium azide.

基本信息

MDL编号 MFCD02096210
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
偶联物 unconjugated
抗体形式 IgG fraction of antiserum
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen 45 kDa (non-apoptotic cells)
species reactivity human
technique(s) western blot: 0.5 μg/mL using human HeLa cell extract
UniProt登记号 O00273
运输 dry ice
储存温度 ?20℃
Gene Information human ... DFFA(1676)

Sigma-Aldrich

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