半岛bd体育手机客户端 说明
一般描述
An acetoxime analog of BIO, GSK-3 Inhibitor IX (Cat. No. 361550) that exhibits greater selectivity for GSK-3α/β (IC50= 10 nM) over Cdk5/p25, Cdk2/cyclin A, and Cdk1/cyclin B (IC50= 2.4 ?M, 4.3 ?M, and 63 ?M, respectively). A weak inhibitor of Cdk4/cyclin D1 and many other non-related kinases (IC50≥ 10 ?M). Yields BIO (Cat. No. 361550) upon hydrolysis.
An acetoxime analog of BIO, GSK-3 Inhibitor IX (Cat. No. 361550) that exhibits greater selectivity for GSK-3α/β (IC50= 10 nM) over Cdk5/p25, Cdk2/A and Cdk1/B (IC50= 2.4 ?M, 4.3 ?M and 63 ?M, respectively). Weakly affects the activities of Cdk4/D1 and many other kinases (IC50≥ 10 ?M). Also acts as an aryl hydrocarbon receptor agonist in both yeast (EC50≥ 0.1 ?M) and mammalian (EC50= 0.16 ?M) reporter systems.
包装
1 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Product does not compete with ATP.
Target IC50: 10 nM against GSK-3α/β
Primary Target
GSK-3α/β
Reversible: no
Cell permeable: no
警告
Toxicity: Carcinogenic / Teratogenic (D)
制备说明
Limited solubility in aqueous buffers; serial dilutions in DMSO may be required prior to dilution in buffer.
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
其他说明
Knockaert, M., et al. 2004.Oncogene23,4400.
Polychronopoulos, P., et al. 2004.J. Med. Chem.47,935.
Meijer, L., et al. 2003.Chem. Biol.10,1255.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C18H12BrN3O3 |
| 分子量 | 398.21 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥95% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 颜色 | dark purple |
| 溶解性 | DMSO: 10 mg/mL |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
