半岛bd体育手机客户端 说明
一般描述
1α-Hydroxyvitamin D3, also known as alfacalcidol, is a synthetic vitamin D3analogue, hydroxylated in position one. It is metabolized to 1,25-dihydroxycholecalciferol by 25-hydroxylases.
生化/生理作用
1α-Hydroxyvitamin D3facilitates calcium absorption and deposition. It also has an ability to inhibit bone resorption and stimulate bone formation. Alfacalcidol is used for treating various bone diseases such as rickets/osteomalacia, renal osteodystrophy and osteoporosis. It acts as a chemopreventive agent and reduces the risk colitis and carcinogenesis.
Synthetic vitamin D3analog that is metabolized to 1,25-dihydroxycholecalciferol. Inhibits bone resorption and stimulates bone formation. Supresses parathyroid hormone secretion by bovine parathyroid cells.
包装
Bottomless glass bottle. Contents are inside inserted fused cone.
基本信息
| 经验(实验)分子式 | C27H44O2 |
| 分子量 | 400.64 |
| EC 号 | 255-297-1 |
| MDL编号 | MFCD00868328 |
| PubChem化学物质编号 | 57647693 |
| NACRES | NA.79 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 生物来源 | synthetic |
| 测定 | ≥97.0% (HPLC) |
| 形式 | powder or crystals |
| 颜色 | white to off-white |
| 储存温度 | ?20℃ |
| SMILES string | CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C3\C[C@@H](O)C[C@H](O)C3=C |
| InChI | 1S/C27H44O2/c1-18(2)8-6-9-19(3)24-13-14-25-21(10-7-15-27(24,25)5)11-12-22-16-23(28)17-26(29)20(22)4/h11-12,18-19,23-26,28-29H,4,6-10,13-17H2,1-3,5H3/b21-11+,22-12-/t19-,23-,24-,25+,26+,27-/m1/s1 |
| InChI key | OFHCOWSQAMBJIW-AVJTYSNKSA-N |
| Gene Information | human ... VDR(7421) |
安全信息
| 象形图 |  |
| 警示用语： | Danger |
| 危险声明 | H300 |
| 预防措施声明 | P301 + P330 + P331 + P310 |
| 危险分类 | Acute Tox. 1 Oral |
| 储存分类代码 | 6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
Sigma-Aldrich
m.cnreagent.com
