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Anti-Tryptophan Hydroxylase antibody produced in sheep

品牌
Sigma-Aldrich
货号
T8575
规格纯度
affinity isolated antibody, buffered aqueous glycerol solution
价格
4731.57 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
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半岛bd体育手机客户端 名称:
Anti-Tryptophan Hydroxylase antibody produced in sheep
Anti-TPH
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The tryptophan hydroxylase 1 (TPH1) gene spanning 29kbp with 11 exons is mapped to human chromosome 11p15.3-p14. TPH1, is a 444 amino acid protein expressed in the gut, spleen, thymus and also in the pineal gland and the pituitary.
Tryptophan Hydroxylase (TPH) is a member of the aromatic amino acid hydroxylases (AAAH) family.

免疫原

recombinant rabbit tryptophan hydroxylase, isolated as inclusion bodies from E. coli and purified by preparative SDS-PAGE.

应用

Anti-Tryptophan Hydroxylase antibody produced in sheep has been used in:

  • immunocytochemistry
  • immunohistochemistry
  • immunofluorescence
  • immunoperoxidase staining

生化/生理作用

The tryptophan hydroxylase 1 gene (TPH1) catalyzes the synthesis of 5-hydroxytryptophan, which is a precursor to the neurotransmitter serotonin. Variation in the gene expression affects prefrontal cortex activation during response inhibition. Mutation in the TPH1 gene leads to schizophrenia, irritable bowel syndrome (IBS) in women, suicidal behavior and depressive disorders. The encoded protein plays a vital role in regulation of cardiovascular function.

外形

Solution in 150 mM NaCl, 10 mM HEPES, pH 7.5, 100 μg per mL BSA, and 50% glycerol.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD00282500
NACRESNA.41

半岛bd体育手机客户端 性质

质量水平200
生物来源sheep
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous glycerol solution
用途 sufficient for 10 blots
species reactivityhuman, mammals
technique(s)western blot: 1:1,000 using human dorsal raphe nucleus
UniProt登记号P17752
运输wet ice
储存温度−20℃
Gene Informationhuman ... TPH1(7166)
mouse ... Tph1(21990)
rat ... Tph1(24848)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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