N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-trifluoromethylcoumarin

半岛bd体育手机客户端 说明

Amino Acid Sequence

NAc-Asp-Glu-Val-Asp-AFC

生化/生理作用

A fluorogenic substrate for caspase 3, a protease that is rapidly activated when cells are exposed to apoptotic conditions and that cleaves poly(ADP-ribose) polymerase. The 7-amido-4-trifluoromethylcoumarin derivative has better membrane permeability than the 7-amido-4-methylcoumarin derivative (A1086).

包装

Bottomless glass bottle. Contents are inside inserted fused cone.

基本信息

经验(实验)分子式	C30H34F3N5O13
分子量	729.61
MDL编号	MFCD01310970
PubChem化学物质编号	329770614
NACRES	NA.32

半岛bd体育手机客户端 性质

质量水平	200
测定	≥90% (HPLC)
形式	powder
颜色	white
溶解性	H2O: 1 mg/mL
储存温度	?20℃
SMILES string	CC(C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H](CC(O)=O)C(=O)Nc1ccc2c(OC(=O)C=C2C(F)(F)F)c1
InChI	1S/C30H34F3N5O13/c1-12(2)25(38-26(47)17(6-7-21(40)41)36-28(49)18(10-22(42)43)34-13(3)39)29(50)37-19(11-23(44)45)27(48)35-14-4-5-15-16(30(31,32)33)9-24(46)51-20(15)8-14/h4-5,8-9,12,17-19,25H,6-7,10-11H2,1-3H3,(H,34,39)(H,35,48)(H,36,49)(H,37,50)(H,38,47)(H,40,41)(H,42,43)(H,44,45)/t17-,18-,19-,25-/m0/s1
InChI key	GZDRODOYEFEHGG-NUDCOPPTSA-N
Gene Information	human ... CASP3(836)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)