半岛bd体育手机客户端 说明
一般描述
A hydroxamate-based inhibitor of collagenase, gelatinase, and TACE (TNF-α converting enzyme/ADAM17; IC50= 100 nM). Blocks spontaneous and PMA-induced release of TNF-α in transfected COS 7 cells.
A hydroxymate-based inhibitor of collagenase, gelatinase, and TACE [(TNF-α convertase; ADAM17 (IC50= 100 nM)]. Blocks spontaneous and PMA-induced release of TNF-α from transfected COS-7 cells.
包装
1 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Target IC50: 100 nM against TACE (TNF-α converting enzyme/ADAM17)
Primary Target
TNF-α converting enzyme/ADAM17
Product does not compete with ATP.
Reversible: no
Cell permeable: no
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
其他说明
Hooper, N.M., et al. 1997.Biochem. J.321,265.
Mullberg, J., et al. 1995.J. Immunol.155,5198.
Mohler, K.M., et al. 1994.Nature370,218.
法律信息
Manufactured exclusively by Peptides International, Louisville, Kentucky, USA.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C24H32N4O5 |
| 分子量 | 456.53 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥96% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze desiccated (hygroscopic) protect from light |
| 颜色 | white |
| 溶解性 | 50% acetic acid: 1 mg/mL DMSO: 5 mg/mL |
| 运输 | ambient |
| 储存温度 | ?20℃ |
| InChI | 1S/C24H32N4O5/c1-14(2)10-19(13-21(29)28-33)23(31)27-20(24(32)26-15(3)22(25)30)12-16-8-9-17-6-4-5-7-18(17)11-16/h4-9,11,14-15,19-20,33H,10,12-13H2,1-3H3,(H2,25,30)(H,26,32)(H,27,31)(H,28,29)/t15-,19?,20-/m0/s1 |
| InChI key | CRCPLBFLOSEABN-VBSNWNEZSA-N |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
