半岛bd体育手机客户端 说明
一般描述
A potent, cell-permeable, reversible, and ATP-competitive inhibitor of Src-family protein tyrosine kinases. Inhibits Src (IC50= 280 nM) as well as closely related kinases Fyn (IC50= 170 nM), Yes (IC50= 20 nM) and Lyn (IC50= 130 nM). The inhibition is competitive with respect to ATP. Has only a trivial effect on Lck (IC50= 6.88 ?M). Does not affect the activity of PDGF-β receptor kinase (IC50≥10 ?M) and IGF-1 receptor kinase (IC50≥20 ?M).
A potent, cell-permeable, reversible, and ATP-competitive Src family kinase inhibitor. Inhibits Src (IC50= 280 nM) as well as closely related kinases such as Fyn (IC50= 170 nM) and Yes (IC50= 20 nM) and Lyn (IC50= 130 nM). Acts as a weak inhibitor of Lck (IC50= 688 ?M) and PDGF receptor kinase (IC50>10 ?M). A 10 mM (500 ?g/135 ?l) solution of SU6656 (Cat. No. 572636) in DMSO is also available.
包装
1 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Cell permeable: yes
Target IC50: 280 nM, 170 nM, 20 nM, and 130 nM against Src, Fyn, Yes, and Lyn.
Product competes with ATP.
Reversible: yes
警告
Toxicity: Standard Handling (A)
其他说明
Bowman, T., et al. 2001.Proc. Natl. Acad. Sci. USA98,7319.
Blake, R.A., et al. 2000.Mol. Cell. Biol.20,9018.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C19H21N3O3S |
| 分子量 | 371.45 |
| MDL编号 | MFCD10565928 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥97% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 颜色 | burnt orange |
| 溶解性 | DMSO: 25 mg/mL |
| 运输 | ambient |
| 储存温度 | ?20℃ |
| InChI | 1S/C19H21N3O3S/c1-22(2)26(24,25)14-7-8-18-15(11-14)16(19(23)21-18)10-13-9-12-5-3-4-6-17(12)20-13/h7-11,20H,3-6H2,1-2H3,(H,21,23)/b16-10+ |
| InChI key | LOGJQOUIVKBFGH-MHWRWJLKSA-N |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
