RSK Inhibitor, SL0101

半岛bd体育手机客户端 说明

一般描述

A cell-permeable Kaempferol (Cat. No. 420345) glycoside that targets the the N-terminal kinase domain of p90 ribosomal S6 kinase and inhibits RSK kinase activity (IC₅₀= 89 nM with 10 ?M ATP) in a selective, reversible, and ATP-competitive (K_i= 1 ?M) manner. Shown to inhibit the proliferation of MCF-7, but not the normal breast cell line MCF-10A, and specifically block PDB-induced cellular phosphorylation of RSK substrate p140, but not that of RSK or RSK upstream kinases even at concentrations as high as 100 ?M. Also available as a 10 mM solution in DMSO (Cat. No. 559292).
A cell-permeable Kaempferol (Cat. No. 420345) glycoside that targets the the N-terminal kinase domain of p90 ribosomal S6 kinase and inhibits RSK kinase activity (IC₅₀= 89 nM with 10 ?M ATP) in a selective, reversible, and ATP-competitive (K_i= 1 ?M) manner. Shown to inhibit the proliferation of MCF-7, but not the normal breast cell line MCF-10A, and specifically block PDB-induced cellular phosphorylation of RSK substrate p140, but not that of RSK or RSK upstream kinases even at concentrations as high as 100 ?M.

包装

1 mg in Plastic ampoule
Packaged under inert gas

警告

Toxicity: Regulatory Review (Z)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Smith, J.A., et al. 2007.Bioorg. Med. Chem.15,5018.
Smith, J.A., et al. 2006.Bioorg. Med. Chem.14,6043.
Xu, Y.M., et al. 2006.Bioorg. Med. Chem.14,3974.
Maloney, D.J. and Hecht, S.M., 2005.Org. Lett.7,1097.
Smith, J.A., et al. 2005.Cancer Res.65,1027.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C25H24O12
分子量	516.45

半岛bd体育手机客户端 性质

质量水平	100
测定	≥95% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze protect from light
颜色	yellow
溶解性	DMSO: 10 mg/mL
运输	ambient
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable