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位置:首页 > 品牌 > Sigma-Aldrich > Raf Kinase Inhibitor IV-CAS 303727-31-3-Calbiochem

Raf Kinase Inhibitor IV-CAS 303727-31-3-Calbiochem

品牌
Sigma-Aldrich
CAS
303727-31-3
货号
553014
规格纯度
The Raf Kinase Inhibitor IV, also referenced under CAS 303727-31-3, controls the biological activity of Raf Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
价格
2566.78 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
303727-31-3
Raf Kinase Inhibitor IV-CAS 303727-31-3-Calbiochem
2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole, L 779450
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable triarylimidazole compound that acts as a reversible, ATP-competitive, and highly potent inhibitor of Raf kinase (IC50 = 10 nM & Kd = 2.4 nM for B-raf) with 7-, 30-, and 70-fold selectivity over p38α, GSK-3β, and Lck, respectively. Cellular data have indicated that the compound is more effective towards Raf-1and A-Raf than B-Raf.
A cell-permeable triarylimidazole compound that acts as a reversible, ATP-competitive, and highly potent inhibitor of Raf kinase (IC50 = 10 nM and Kd = 2.4 nM for B-raf) with 7-, 30-, and 70-fold selectivity over p38α, GSK-3β, and Lck, respectively. Cellular data have indicated that the compound is more effective towards Raf-1and A-Raf than B-Raf.

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Kd = 2.4 nM for B-raf
Product competes with ATP.
Reversible: yes
Primary Target
Raf Kinase

警告

Toxicity: Irritant (B)

其他说明

Takle, A.K., et al. 2006. Bioorg. Med. Chem. Lett.16, 378.
Shelton, J.G., et al. 2003. Leukemia17, 1765.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C20H14ClN3O
分子量347.80
MDL编号MFCD12828750

半岛bd体育手机客户端 性质

质量水平100
测定≥97% (HPLC)
形式solid
效能10 nM IC50
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 off-white
溶解性ethanol: 10 mg/mL
DMSO: 100 mg/mL
运输ambient
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3

Sigma-Aldrich

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