PKG Iα Inhibitor, Cell-Permeable-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A highly potent, reversible, and substrate competitive membrane-permeableDrosophilaAntennapedia homeodomain fused-peptide that selectively inhibits protein kinase G Iα (K_i= 25 nM). Shown to efficiently translocate into arterial smooth muscle cells and inhibit NO-induced vasodilation (ED₅₀= 47 ?M). Inhibits protein kinase A at much higher concentrations (K_i= 493 ?M). The carrier peptide is also available under Cat. no. 287895.
A highly potent, reversible, and substrate competitive membrane-permeable peptide that selectively inhibits protein kinase G Iα (PKG Iα) (K_i= 25 nM). Inhibitor peptide is fused to the Drosophila Antennapedia homeo domain peptide to allow membrane permeability. Shown to efficiently cross the membrane of arterial smooth muscle cells and inhibit nitric oxide-induced (NO-induced) vasodilation (EC₅₀= 47 ?M). Inhibits protein kinase A (PKA) activity only at much higher concentrations (K_i= 493 ?M). The carrier peptide is also available under Cat. no. 287895.

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Target K_i: 25 nM against protein kinase G Iα
Primary Target
PKG1α
Reversible: yes
Cell permeable: yes
Product competes with ATP.

警告

Toxicity: Standard Handling (A)

序列

H-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Leu-Arg-Lys-Lys-Lys-Lys-Lys-His-OH

外形

Supplied as a trifluoroacetate salt.

重悬

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

其他说明

Dostmann, W. R.G., et al. 2000.Proc. Natl. Acad. Sci. USA97,14772.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C152H258N52O28S
分子量	3294.07

半岛bd体育手机客户端 性质

质量水平	100
测定	≥95% (HPLC)
形式	lyophilized
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze desiccated (hygroscopic)
溶解性	DMSO: 10 mg/mL
运输	ambient
储存温度	?20℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable