半岛bd体育手机客户端 说明
一般描述
A cell-permeable 2-hydroxy-1-napthaldehyde derivative that acts as a specific and a direct inhibitor of sirtuin class of histone deacetylase (HDAC) activity. Does not affect human HDAC1. Reported to block Sir2p transcriptional silencing activityin vivo(IC50= 25 ?M) and NAD-dependent HDAC activity in purified recombinant yeast Sir2p and human SIRT2in vitro(IC50= 68 ?M and 38 ?M, respectively).
包装
1 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Cell permeable: yes
Primary Target
ySir2
Product does not compete with ATP.
Reversible: no
Target IC50: 48 ?M, 131 ?M and 58 ?M for ySir2, hSIRT1 and hSIRT2, respectively
警告
Toxicity: Irritant (B)
外形
A 10 mM (1 mg/254 ?l) solution of Sirtinol (Cat. No. 566320) in DMSO.
重悬
Following initial thaw, aliquot and refrigerate (4°C).
其他说明
Mai, A., et al. 2005.J. Med. Chem.48,7789.
Grozinger, C.M., et al. 2001.J. Biol. Chem.276,38837.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C26H22N2O2 |
| 分子量 | 394.47 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥97% (HPLC) |
| 形式 | liquid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze desiccated (hygroscopic) protect from light |
| 运输 | wet ice |
| 储存温度 | 2-8℃ |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 1 |
| 闪点(F) | 188.6 °F - (Dimethylsulfoxide) |
| 闪点(C) | 87 ℃ - (Dimethylsulfoxide) |
Sigma-Aldrich
m.cnreagent.com
