InSolution PP2-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A potent and selective inhibitor of thesrcfamily of tyrosine kinases. Its action is similar to PP1. Selectively inhibits p56^lck(IC₅₀= 4 nM), p59^fynT(IC₅₀= 5 nM), and Hck (IC₅₀= 5 nM) compared to other tyrosine kinases, such as EGF-R (IC₅₀= 480 nM), JAK2 (IC₅₀>50 ?M) or ZAP-70 (IC₅₀>100 ?M). Also potently inhibits anti-CD3-stimulated tyrosine phosphorylation of human T cells (IC₅₀= 600 nM).

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Primary Target
p56^lck
Product competes with ATP.
Target IC₅₀: 4 nM, 5 nM, 5 nM, 100 nM, against p56lck, p59fynT, Hck , and Src, respectively; 600 nM against anti-CD3-stimulated tyrosine phosphorylation of human T cells
Cell permeable: no
Reversible: yes

警告

Toxicity: Irritant (B)

外形

A 10 mM (1 mg/331 ?l) solution of PP2 (Cat. No. 529573) in DMSO.

重悬

Following initial thaw, aliquot, purge with inert gas, and freeze (-20°C).

其他说明

Hanke, J.H., et al. 1996.J. Biol. Chem.271, 695.



Selected Citations
Lee, J., et al. 2009. Cell Stem Cell 5,76.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C15H16ClN5
分子量	301.77

半岛bd体育手机客户端 性质

质量水平	100
测定	≥95% (HPLC)
形式	liquid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze protect from light
颜色	clear colorless
运输	wet ice
储存温度	?20℃

安全信息

储存分类代码	10 - Combustible liquids
WGK	WGK 2
闪点(F)	188.6 °F - (Dimethylsulfoxide)
闪点(C)	87 ℃ - (Dimethylsulfoxide)