InSolution p38 MAP Kinase Inhibitor III-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A cell-permeable, potent, selective, and ATP-competitive inhibitor of p38 MAP kinase (IC₅₀= 380 nM for p38α). Shown to effectively suppress LPS-induced cytokine release in vitro (IC₅₀= 160 nM for TNF-α release and 39 nM for IL-1β release, human PBMC) andin vivo(ED₅₀= 1.33 mg/kg for TNF-α release in mice). Exhibits reduced inhibitory activity against cytochrome P450-2D6 compared to SB 203580 (Cat. No 559389) and is better suited for use in animal models.

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Product competes with ATP.
Target IC₅₀: 0.38 ?M for p38α; 0.16 and 0.039 ?M in suppressing LPS-induced TNF-α and IL-1β release, respectively, in human PBMC; ED50 = 1.33 mg/kg in suppressing LPS-induced TNF-α release in mouse
Primary Target
p38 MAP kinase
Reversible: yes

警告

Toxicity: Standard Handling (A)

外形

A 10 mM (1 mg/247 ?l) solution of p38 MAP Kinase Inhibitor III (Cat. No. 506121) in DMSO.

重悬

Following initial use, aliquot and refrigerate (4°C).

其他说明

Laufer, S.A., et al. 2003.J. Med. Chem.46,3230.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C23H21FN4S
分子量	404.50

半岛bd体育手机客户端 性质

质量水平	100
测定	≥98% (HPLC)
形式	liquid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze desiccated (hygroscopic) protect from light
运输	wet ice
储存温度	2-8℃

安全信息

储存分类代码	10 - Combustible liquids
WGK	WGK 1
闪点(F)	188.6 °F - (Dimethylsulfoxide)
闪点(C)	87 ℃ - (Dimethylsulfoxide)