半岛bd体育手机客户端 说明
一般描述
A cell-permeable, potent, reversible, ATP-competitive and highly selective inhibitor of IKK-2 (IC50~3-12 ?M for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2) that also displays anti-inflammatory properties. Specificity has been reported using a panel of 31 additional kinases, including IKK isoforms IKK-1, IKK-i, and TBK-1 (IC50>200 ?M). Shown to specifically block NF-κB-dependent gene expression, but not MAP kinase pathways, in stimulated RASF synovial fibroblast cells. Does not inhibit the phosphorylation and activation of the IKK complex.
包装
1 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Cell permeable: yes
Target IC50: ~ 3-12 ?M for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2
Primary Target
IKK-2
Product competes with ATP.
Reversible: yes
警告
Toxicity: Irritant (B)
外形
A 25 mM (1 mg/178 ?l) solution of IKK-2 Inhibitor, SC-514 (Cat. No. 401479) in DMSO.
重悬
Following initial use, aliquot and refrigerate (4°C).
其他说明
Baxter, A., et al. 2004Bioorg. Med. Chem. Lett.14, 2817.
Kishore, N., et al. 2003.J. Biol. Chem.278, 32861.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C9H8N2OS2 |
| 分子量 | 224.30 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥95% (HPLC) |
| 形式 | liquid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze desiccated (hygroscopic) protect from light |
| 颜色 | clearpale yellow |
| 运输 | wet ice |
| 储存温度 | 2-8℃ |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 2 |
| 闪点(F) | 188.6 °F - (Dimethylsulfoxide) |
| 闪点(C) | 87 ℃ - (Dimethylsulfoxide) |
Sigma-Aldrich
m.cnreagent.com
