InSolution G? 6976-CAS 136194-77-9-Calbiochem

半岛bd体育手机客户端 说明

一般描述

Inhibitor of protein kinase C (PKC; IC₅₀= 7.9 nM for rat brain). Selectively inhibits Ca²⁺-dependent PKC_α-isozyme (IC₅₀= 2.3 nM) and PKC_βI(IC₅₀= 6.2 nM). Does not affect the kinase activity of the Ca²⁺-independent PKC δ-, ε-, and ζ-isoenzymes even at micromolar levels. A potent antagonist of HIV-1 induction.

包装

1 ml in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Product competes with ATP.
Target IC₅₀: 7.9 nM, 2.3 nM, and 6.2 nM, for rat brain PKC, Ca2+-dependent PKC α-isozyme, and PKCβI, respectively
Reversible: yes
Primary Target
PKC

警告

Toxicity: Irritant (B)

外形

A 500 ?g/ml solution of G? 6976 (Cat. No. 365250) in anhydrous DMSO.

重悬

Following initial thaw, aliquot and freeze (-20°C).

其他说明

Gschwendt, M., et al. 1996.FEBS Lett.392,77.
Wenzel-Seifert, K., et al. 1994.Biochem. Biophys. Res. Commun.200,1536.
Martiny-Baron, G., et al. 1993.J. Biol. Chem.268,9194.
Qatsha, K.A., et al. 1993.Proc. Natl. Acad. Sci. USA90,674.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C24H18N4O
分子量	378.43
MDL编号	MFCD00236434

半岛bd体育手机客户端 性质

质量水平	100
测定	≥95% (HPLC)
形式	liquid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze protect from light
溶解性	DMSO: 5 mg/mL
运输	wet ice
储存温度	?20℃
InChI	1S/C24H18N4O/c1-27-17-9-4-2-7-14(17)20-21-16(13-26-24(21)29)19-15-8-3-5-10-18(15)28(12-6-11-25)23(19)22(20)27/h2-5,7-10H,6,12-13H2,1H3,(H,26,29)
InChI key	VWVYILCFSYNJHF-UHFFFAOYSA-N

安全信息

储存分类代码	10 - Combustible liquids
WGK	WGK 1
闪点(F)	188.6 °F - (Dimethylsulfoxide)
闪点(C)	87 ℃ - (Dimethylsulfoxide)