半岛bd体育手机客户端 说明
一般描述
A cell-permeable, potent, and selective inhibitor of Akt1/Akt2 activity (IC50= 58 nM, 210 nM, and 2.12 ?M for Akt1, Akt2, and Akt3, respectively, inin vitrokinase assays). The inhibition is reported to be pleckstrin homology (PH) domain-dependent. It does not exhibit any inhibitory effect against PH domain-lacking Akts, or other closely related AGC family kinases, PKA, PKC, and SGK, even at concentrations as high as 50 ?M. Overcomes Akt1/Akt2-mediated resistance to chemotherapeutics in tumor cells and is shown to block basal and stimulated phosphorylation/activation of Akt1/Akt2 both in cultured cellsin vitroand in micein vivo.
包装
1 mg in Plastic ampoule
Packaged under inert gas
Please refer to vial label for lot-specific concentration.
生化/生理作用
Primary Target
Akt1, Akt2, Akt3
Product does not compete with ATP.
Reversible: yes
Cell permeable: yes
Target IC50: 58 nM, 210 nM, and 2.12 ?M for Akt1, Akt2, and Akt3, respectively, inin vitrokinase assays
警告
Toxicity: Irritant (B)
外形
A 10 mM (1 mg/181 ?l) solution of Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 (Cat. No. 124018) in DMSO.
重悬
Following initial thaw, aliquot and freeze (-70°C).
其他说明
Barnett, S.F., et al. 2005.Biochem. J.385,399.
DeFeo-Jones, D., et al. 2005.Mol. Cancer Ther.4,271.
Zhao, Z., et al. 2005.Bioorg. Med. Chem. Lett.15,905.
Lindsley, C.W., et al. 2005.Bioorg. Med. Chem. Lett.15,761.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C34H29N7O |
| 分子量 | 551.64 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥95% (HPLC) |
| 形式 | liquid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze desiccated (hygroscopic) protect from light |
| 运输 | wet ice |
| 储存温度 | ?70℃ |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 2 |
| 闪点(F) | 188.6 °F - (Dimethylsulfoxide) |
| 闪点(C) | 87 ℃ - (Dimethylsulfoxide) |
Sigma-Aldrich
m.cnreagent.com
