半岛bd体育手机客户端 说明
一般描述
Highly potent and specific inhibitor of the epidermal growth factor (EGF) receptor tyrosine kinase (IC50= 3 nM). Much higher concentrations are required for inhibition of the kinase activity of the closely related HER2 (neu/erb-B2) receptor (IC50>100 ?M), the platelet-derived growth factor (PDGF) receptor (IC50>100 ?M), and p210Bcr-Abl(IC50>50 ?M). Its mechanism of inhibition likely mimics that of the related compound, 4-(3-chloroanilino)quinazoline (CAQ), a competitive inhibitor with respect to ATP.
包装
1 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Primary Target
Epidermal growth factor receptor kinase
Reversible: yes
Cell permeable: yes
Product competes with ATP.
Target IC50: 3 nM against of epidermal growth factor receptor kinase
警告
Toxicity: Irritant (B)
外形
A 10 mM (1 mg/317 ?l) solution of AG 1478 (Cat. No. 658552) in DMSO.
重悬
Following initial thaw, aliquot and freeze (-20°C).
其他说明
Levitski, A., and Gazit, A. 1995.Science267,1782.
Fry, D.W., et al. 1994.Science265,1093.
Osherov, N., and Levitski, A. 1994.Eur. J. Biochem.225,1047.
Ward, W.H., et al. 1994. Biochem. Pharmacol. 48, 659.
法律信息
Sold under license of U.S. Patent 5,457,105 and European Patent 0,566,266.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C16H14ClN3O2 |
| 分子量 | 315.75 |
| MDL编号 | MFCD00270914 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | liquid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 颜色 | clearfaint tan |
| 运输 | wet ice |
| 储存温度 | ?20℃ |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 2 |
| 闪点(F) | 188.6 °F - (Dimethylsulfoxide) |
| 闪点(C) | 87 ℃ - (Dimethylsulfoxide) |
Sigma-Aldrich
m.cnreagent.com
