Hsp25 Kinase Inhibitor-Calbiochem

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一般描述

A 13-residue, cell-permeable peptide that acts as a potent and selective inhibitor of mammalian heat-shock protein (Hsp25) kinase. Inhibits Hsp25 kinase competitively with respect to the substrate peptide (K_i = 8.1 µM) and non-competitive with respect to ATP (K_i = 134 µM). [Hsp 25 kinase is also called mitogen-activated protein kinase-activated protein kinase-2 (MK2).]
A 13-residue, cell-permeable peptide that acts as a potent and selective inhibitor of mammalian heat-shock protein (Hsp25) kinase [also called mitogen-activated protein kinase-activated protein kinase-2 (MAPKAP kinase-2)]. Inhibition is competitive with respect to the substrate peptide (K_i = 8.1 µM) and non-competitive with respect to ATP (K_i = 134 µM).

包装

1 mg in Plastic ampoule

生化/生理作用

Target K_i: 8.1 µM against (Hsp25) kinase
Product does not compete with ATP.
Cell permeable: yes
Primary Target
(Hsp25) kinase
Reversible: no

警告

Toxicity: Standard Handling (A)

序列

H-Lys-Lys-Lys-Ala-Leu-Asn-Arg-Gln-Leu-Gly-Val-Ala-Ala-OH

外形

Supplied as a trifluoroacetate salt.

重悬

Following recosntitution, aliquot and freeze (-20°C). Stock solutions are stable for up to months at -20°C.

其他说明

Katsoulidis, E., et al. 2005. Cancer Res.65, 9029.
Hayess, K., and Benndorf, R. 1997. Biochem. Pharmacol. 53, 1239.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

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