半岛bd体育手机客户端 说明
一般描述
A cell-permeable, reversible and selective peptidomimetic inhibitor of γ-secretase (IC50= 13 ?M for Aβ). Displays only weak inhibitory activity against calpain II (IC50= 100 ?M in a purified enzyme assay).
Please note that the molecular weight for this compound is batch-specific due to variable water content.
A cell-permeable, reversible and selective peptidomimetic inhibitor of γ-secretase with an IC50of 13 ?M for the inhibition of amyloid β-protein (Aβ) production in β-amyloid precursor protein (APP)-transfected Chinese hamster ovary cells. Displays only weak inhibitory activity against calpain II (IC50= 100 ?M in a purified enzyme assay).
包装
1 mg in Plastic ampoule
生化/生理作用
Cell permeable: yes
Primary Target
γ-secretase
Product does not compete with ATP.
Target IC50: 13 ?M against γ-secretase
Reversible: yes
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Wolfe, M.S., et al. 1999.Biochemistry38,4720.
Wolfe, M.S., et al. 1998.J. Med. Chem.41,6.
Citron, M., et al. 1996.Proc. Natl. Acad. Sci. USA93,13170.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C33H57F2N5O9 |
| 分子量 | 705.83 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥95% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze |
| 颜色 | white |
| 溶解性 | DMSO: 10 mM |
| 运输 | ambient |
| 储存温度 | ?20℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
