Cathepsin K Substrate II, Fluorogenic-Calbiochem

半岛bd体育手机客户端 说明

一般描述

An internally quenched, highly cathepsin K-selective, fluorogenic peptide substrate that is efficiently cleaved by CatK (k_cat/K_m= 0.426 ?M^-1S^-1), but not by Cathepsins B/L/S/F/H/V. Studies using WT and CatK^-/-mice reveal that the substrate is not cleaved by other proteolytic enzymes present in fibroblast lysates. Emission Max: 420 NM, Excitation Max: 320 nM.


An internally quenched, highly cathepsin K-selective, fluorogenic peptide substrate that is efficiently cleaved by CatK (k_cat/Km= 0.426 ?M?? S??), but not by Cathepsins B/L/S/F/H/V.
An internally quenched, highly cathepsin K-selective, fluorogenic peptide substrate that is efficiently cleaved by CatK (k_cat/K_m= 0.426 ?M^-1S^-1), but not by Cathepsins B/L/S/F/H/V. Studies using WT and CatK^-/-mice reveal that the substrate is not cleaved by other proteolytic enzymes present in fibroblast lysates.

包装

1 mg in Plastic ampoule
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

序列

Abz-His-Pro-Gly~Gly-Pro-Gln-EDDnp

外形

Supplied as a trifluoroacetate salt.

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Lecaille, F., et al. 2003.Biochem. J.375,307.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C40H50N14O12
分子量	918.91

半岛bd体育手机客户端 性质

质量水平	100
测定	≥95% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze desiccated protect from light
颜色	bright yellow
溶解性	DMSO: 5 mg/mL
荧光	λex320 nm; λem420 nm
运输	wet ice
储存温度	?20℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable