半岛bd体育手机客户端 说明
一般描述
Apoptosis is a normal process in development and morphogenesis. Many cells can be activated to undergo apoptosis following the interaction of selected ligands with cell surface receptors. Receptor-mediated apoptosis involves the activation of caspases (cysteine-containing aspartate-specific proteases). A distinctive feature of caspases is the requirement of an aspartic acid residue in the substrate P1position.
Caspase inhibitors act by binding to the active site of caspases and form either a reversible or an irreversible linkage. Caspase inhibitor design includes a peptide recognition sequence attached to a functional group such as an aldehyde (CHO), chloromethylketone (CMK), fluoromethylketone (FMK), or fluoroacyloxymethylketone (FAOM). Caspase inhibitors with a CHO group are reversible and those with a CMK, FMK, or FAOM group are irreversible and cell-permeable. FMK exhibits slightly less reactivity than CMK and therefore is more specific for the enzyme being inhibited.
A set of eight ready to use cell-permeable, irreversible inhibitors of various caspase-family proteases. Contains 25 ?l (2 mM) each of Caspase-1 Inhibitor VI, Z-YVAD-FMK (Cat. No. 218746); Caspase-2 Inhibitor I, Z-VDVAD-FMK (Cat. No. 218744); Caspase-3 Inhibitor II, Z-DEVD-FMK (Cat. No. 264155); Caspase-5 Inhibitor I, Z-WEHD-FMK (Cat. No. 218753); Caspase-6 Inhibitor I, Z-VEID-FMK (Cat. No. 218757); Caspase-8 Inhibitor II, Z-IETD-FMK (Cat. No. 218759); Caspase-9 Inhibitor I, Z-LEHD-FMK (Cat. No. 218761); and Caspase Inhibitor I, Z-VAD-FMK (Cat. No. 627610). Supplied with a data sheet.
包装
1 set in Glass bottle
生化/生理作用
Cell permeable: yes
Reversible: no
Primary Target
Caspase-1, caspase-2, caspase-3, caspase-4, caspase-5, caspase-6, caspase-7, caspase-8
警告
Toxicity: Irritant (B)
外形
Supplied as 2 mM in DMSO.
其他说明
Humke, E.W., et al. 1998.J. Biol. Chem.273,15702.
Datta, R., et al. 1997.J. Biol. Chem.272,1965.
Martin, L.M., et al. 1997.J. Biol. Chem.272,7421.
Takahashi, A., et al. 1997.Exp. Cell Res.231,123.
Talanian, R.V., et al. 1997.J. Biol. Chem.272,9677.
Thornberry, N.A., et al. 1997.J. Biol. Chem.272,17907.
Nicholson, D.W., et al. 1995.Nature376,37.
Thornberry, N.A., et al. 1992.Nature356,768.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 形式 | liquid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze desiccated |
| 运输 | wet ice |
| 储存温度 | ?20℃ |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
Sigma-Aldrich
m.cnreagent.com
