半岛bd体育手机客户端 说明
一般描述
A cell-permeable isophthalamide compound containing hydroxyethylamine motif that binds to BACE-1 active site and potently blocks its proteolytic activity (IC50= 15 nM for BACE-1, human and 29 nM for sAPP_NF in HEK293-APPNFEVcells). Displays greater selectivity over other aspartyl proteases (IC50= 0.23 ?M, 7.6 ?M and >50 ?M for BACE-2, cathepsin D, and renin, respectively). Also available as a 10 mM solution in DMSO (Cat. No. 565794).
Please note that the molecular weight for this compound is batch-specific due to variable water content.
A cell-permeable and potent inhibitor that binds to BACE-1 active site and blocks its proteolytic activity (IC50= 15 nM for BACE-1, human and 29 nM for sAPP_NF in HEK293-APPNFEVcells). Displays greater selectivity over other aspartyl proteases (IC50= 230 nM, 7.6 ?M and >50 ?M for BACE-2, cathepsin D, and renin, respectively).
包装
1 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Primary Target
BACE-1 human
Product does not compete with ATP.
Cell permeable: yes
Reversible: no
Target IC50: 15 nM for BACE-1, human and 29 nM for sAPP_NF in HEK293-APPNFEV cells
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Halima, S.B., et al. 2016.Cell Reports.14,In press.
Stachel, S.J., et al. 2004.J. Med. Chem.47,6447.
Solubilize in DMSO (10 mg/ml), aliquot & store at -20*C; stable for 3 months.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C31H38N4O5S |
| 分子量 | 578.72 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 颜色 | white |
| 溶解性 | DMSO: 100 mg/mL |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
