Anthrax Lethal Factor Protease Inhibitor, In-2-LF-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A cell-permeable derivative of a 14-mer peptide that is based on the MEK-2 template and acts as a competitive inhibitor of Anthrax lethal factor metalloprotease (K_i= 1 nM). Also inhibits MEK-3 cleavage. Exhibits protective effects against Anthrax toxin-induced cytotoxicity in RAW264.7 and J772.A1 cells. Reported to competitively inhibit furin (K_i= 49 nM.
A cell-permeable N-acetylated, C-hydroxamate derivative of a 14-mer peptide designed from the MEK-2 template that acts as a competitive inhibitor of Anthrax lethal factor (LF) metalloprotease (K_i= 1 nM). Also inhibits MEK-3 cleavage. Protects against Anthrax toxin induced cytotoxicity in RAW264.7 and J772.A1 cells.

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Primary Target
anthrax LF metalloprotease
Product does not compete with ATP.
Cell permeable: yes
Target K_i: 1 nM against Anthrax lethal factor (LF) metalloprotease
Reversible: no

警告

Toxicity: Standard Handling (A)

序列

Ac-Gly-Tyr-βAla-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Val-Leu-Arg-NHOH

外形

Supplied as a trifluoroacetate salt.

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Peinado, J.R., et al. 2004.Biochem. Biophys. Res. Commun.321,601.
Tonello, F., et. al. 2002.Nature418,386.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C81H150N42O17
分子量	1984.33

半岛bd体育手机客户端 性质

质量水平	100
测定	≥97% (HPLC)
形式	lyophilized solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze desiccated (hygroscopic)
颜色	white
溶解性	water: 1 mg/mL 5% acetic acid: 5 mg/mL DMSO: 5 mg/mL
运输	wet ice
储存温度	?20℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable