VEGF Inhibitor, V1-Calbiochem

品牌

Sigma-Aldrich

货号

676495

包装型号

1 MG, The VEGF Inhibitor, V1 controls the biological activity of VEGF. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

规格纯度

The VEGF Inhibitor, V1 controls the biological activity of VEGF. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

价格

2340.22 元 *本价格含增值税费

促销

数量

- +

半岛bd体育手机客户端名称：

VEGF Inhibitor, V1-Calbiochem
ATWLPPR

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

一般描述

An NRP-1-binding heptapeptide whose target was initially mistaken as VEGFR2/KDR/Flk-1 due to its binding activity to a CHO-KDR culture that was later shown to express primarily NRP-1 and little KDR. V1/A7R specifically competes against VEGF₁₆₅binding to recombinant NRP-1 in cell-free binding assays (IC₅₀= 60 ?M), while exhibiting no activity against the interaction between NRP-1 and heparin or VEGF₁₆₅binding to KDR, VEGFR1/Flt-1, and heparin. V1/A7R is demonstrated to inhibit VEGF-dependent angiogenesis activity in HMVEC (IC₅₀= 0.3 ?M) and HUVEC culturesin vitro, as well as in a rabbit corneal neovascularization model and in mice bearing MDA-MB-231-derived tumorin vivo.
An NRP-1-binding heptapeptide whose target was initially mistaken as VEGFR2/KDR/Flk-1 due to its binding activity to a CHO-KDR culture that was later shown to express primarily NRP-1 and little KDR. V1/A7R specifically competes against VEGF₁₆₅binding to recombinant NRP-1 in cell-free binding assays (IC₅₀= 60 ?M), while exhibiting no activity against the interaction between NRP-1 and heparin or VEGF₁₆₅binding to KDR, VEGFR1/Flt-1, and heparin. V1/A7R is demonstrated to inhibit VEGF-dependent angiogenesis activity in HMVEC (IC₅₀= 0.3 ?M) and HUVEC culturesin vitro, as well as in a rabbit corneal neovascularization model and in mice bearing MDA-MB-231-derived tumorin vivo.

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Primary Target
Specifically competes against VEGF165 binding to recombinant NRP-1
Product does not compete with ATP.
Reversible: no
Cell permeable: no
Target IC₅₀: 60 ?M for specifically competes against VEGF165 binding to recombinant NRP-1 in cell-free binding assays

警告

Toxicity: Standard Handling (A)

序列

H-Ala-Thr-Trp-Leu-Pro-Pro-Arg-OH

其他说明

Starzec, A., et al. 2006.Life Sci.79,2370.
Binetruy-Tournaire, R., et al. 2000.EMBO J.19,1525.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₄₀H₆₁N₁₁O₉
分子量	839.98

半岛bd体育手机客户端性质

质量水平	100
测定	≥95% (HPLC)
形式	lyophilized solid
manufacturer/tradename	Calbiochem^?
储存条件	OK to freeze desiccated (hygroscopic)
颜色	white
溶解性	DMSO: 5 mg/mL
运输	ambient
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable