VEGF Inhibitor, CBO-P11-Calbiochem

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一般描述

A macrocyclic 17-amino acid peptide derived from residues 79 - 93 of vascular endothelial growth factor that mediate its binding to VEGFR-2. It blocks the binding of VEGF₁₆₅to its receptors (IC₅₀= 700 nM for VEGFR1, 1.3 ?M for VEGFR2) and exhibits anti-angiogenic activity as well as other VEGFR-mediated cellular functions, such as proliferation (IC₅₀= 5.8 ?M), migration (IC₅₀= 8.2 ?M), and activation of MAP kinases. Its anti-angiogenic activity has been successfully demonstratedin vivousing chick embryos and nude mice tumor models of human intracranial and syngeneic glioma.
A macrocyclic, 17-amino acid peptide derived from residues 79-93 of vascular endothelial growth factor (VEGF) that mediates the binding of VEGF to its receptor, VEGFR-2. Blocks the binding of VEGF₁₆₅to its receptors (IC₅₀= 70 nM for VEGFR-1, 1.3 ?M for VEGFR-2) and exhibits anti-angiogenic properties. Also reported to block other VEGF-mediated cellular functions such as proliferation (IC₅₀= 5.8 ?M), migration (IC₅₀= 8.2 ?M), and activation of MAP kinases. Also reported to exhibit anti-angiogenic propertiesin vivousing chick embryo and nude mouse tumor models of human intracranial and syngeneic glioma.

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Primary Target
Blocks the binding of VEGF165 to its receptors
Target IC₅₀: 700 nM for VEGFR1, 1.3 ?M for VEGFR2
Product does not compete with ATP.
Reversible: no
Cell permeable: no

警告

Toxicity: Carcinogenic / Teratogenic (D)

序列

cyclic(D-Phe-Pro-Gln-Ile-Met-Arg-Ile-Lys-Pro-His-Gln-Gly-Gln-His-Ile-Gly-Glu)

外形

Supplied as a trifluoroacetate salt.

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Zilberberg, L., et al. 2003.J. Biol. Chem.278,35564.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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