N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine, 2-aminoethyl Amide, TNF-α Protease Inhibitor-1

TAPI-1-CAS 171235-71-5-Calbiochem

品牌

Sigma-Aldrich

CAS

171235-71-5

货号

579051

包装型号

1 MG, TAPI-1, CAS 171235-71-5, is a structural analog of TAPI-0 with similarin vitroefficacy for the inhibition of MMPs and TACE. Blocks the shedding of several cell surface proteins.

规格纯度

TAPI-1, CAS 171235-71-5, is a structural analog of TAPI-0 with similarin vitroefficacy for the inhibition of MMPs and TACE. Blocks the shedding of several cell surface proteins.

价格

6144.27 元 *本价格含增值税费

促销

数量

- +

半岛bd体育手机客户端名称：

171235-71-5
TAPI-1-CAS 171235-71-5-Calbiochem
N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine, 2-aminoethyl Amide, TNF-α Protease Inhibitor-1

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

一般描述

A structural analog of TAPI-0 (Cat. No. 579050) with similar in vitro efficacy for the inhibition of MMPs and TACE (TNF-α convertase; ADAM17). However, TAPI-1 is more stable in serum than TAPI-0. TAPI-1 Blocks the shedding of several cell surface proteins such as TNF-α, IL-6 receptor, and p60 and p80 TNF receptors. Inhibits constitutive (IC₅₀= 8.09 ?M) and muscarinic receptor-stimulated (IC₅₀= 3.61 ?M) sAPPa release in HEK-293 cells expressing muscarinic receptors. Also blocks the TACE-dependent constitutive release of co-transfected APP(695) (IC₅₀= 920 nM).
A structural analog of TAPI-0 (Cat. No. 579050) with similarin vitroefficacy for the inhibition of MMPs and TACE (TNF-α converting enzyme/ADAM17). TAPI-1 also blocks the shedding of several cell surface proteins such as IL-6 receptor, p60 TNF receptor, and p80 TNF receptor. Blocks constitutive (IC₅₀= 8.09 ?M) and muscarinic receptor-stimulated (IC₅₀= 3.61 ?M) sAAPα release in HEK 293 cells expressing M3 muscarinic receptors. A 10 mM (500 ?g/100 ?l) solution of TAPI-1 (Cat. No. 579050) in DMSO is also available.

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Primary Target
MMPs and TACE
Product does not compete with ATP.
Target IC₅₀: 8.09 ?M and 3.61 ?M blocking constitutive and muscarinic receptor-stimulated sAAPα release in HEK 293 cells expressing M3 muscarinic receptors, respectively
Reversible: no
Cell permeable: no

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

其他说明

Slack, B.E., et al. 2001.Biochem. J.357,787.
Vincent, B., et al. 2001.J. Biol. Chem.276,37743.
Hooper, N.M., et al. 1997.Biochem. J.321,265.
Crowe, P.D., et al. 1995.J. Exp. Med.181,1205.
Mullberg, J., et al. 1995.J. Immunol.155,5198.
Mohler, K.M., et al. 1994.Nature370,218.

法律信息

Manufactured exclusively by Peptides International, Louisville, Kentucky, USA.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₂₆H₃₇N₅O₅
分子量	499.60

半岛bd体育手机客户端性质

质量水平	100
测定	≥97% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^?
储存条件	OK to freeze desiccated (hygroscopic) protect from light
颜色	white
溶解性	methanol: 1 mg/mL DMSO: 5 mg/mL
运输	ambient
储存温度	?20℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable