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位置: 首页> 品牌> Sigma-Aldrich> Staurosporine, N-Benzoyl

Staurosporine, N-Benzoyl

品牌
Sigma-Aldrich
CAS
120685-11-2
货号
539648
规格纯度
A cell-permeable Staurosporine derivative that displays antitumor properties.
价格
3736.22 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
120685-11-2
Staurosporine, N-Benzoyl
PKG Inhibitor IX, N-Benzoylstaurosporine, CGP 41 251, PKC412, PDGFR Tyrosine Kinase Inhibitor X
PKG Inhibitor IX, N-Benzoylstaurosporine, CGP 41 251, PDGFR Tyrosine Kinase Inhibitor X, PKC412
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable Staurosporine (Cat. No. 569397) derivative that displays antitumor properties. Acts as a broad-spectrum, reversible, and ATP-competitive inhibitor of PKC (α, β and γ), PDGFRβ, VEGFR2, Syk, PKCη, PKCδ, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1, and EGFR (IC50= 22 nM, 50 nM, 86 nM, 95 nM, 160 nM, 330 nM, 390 nM, 528 nM, 570 nM, 570 nM, 600 nM, 790 nM, 800 nM, 912 nM, and 1.0 ?M, respectively). At higher concentrations, also inhibits Ins-R and IGF-1R (IC50= 10 µM). Shown to potently inhibit the proliferation of Ba/F3 cells expressing constitutively active Flt3 (IC50<10 nM).

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Target IC50: 22 nM, 50 nM, 86 nM, 95 nM, 160 nM, 330 nM, 390 nM, 528 nM, 570 nM, 570 nM, 600 nM, 790 nM, 800 nM, 912 nM, and 1.0 ?M against primary targets in the order listed
Primary Target
PKC (α, β and γ), PDGFRβ, VEGFR2, Syk, PKCη, PKCδ, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1, and EGFR
Product competes with ATP.
Reversible: yes

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Weisberg, E., et al. 2002.Cancer Cell1,433.
Fabbro, D., et al. 2000.Anticancer Drug Des.15,17.
Meyer, T., et al. 1999.Int. J. Cancer81,669.
Meyer, T., et al. 1989.Int. J. Cancer43,851.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C35H30N4O4
分子量 570.64

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
颜色 tan
溶解性 DMSO: 6 mg/mL
运输 ambient
储存温度 ?20℃
InChI 1S/C35H30N4O4/c1-34(42-4)30(37(3)32(41)19-12-6-5-7-13-19)33-38-23-16-10-8-14-20(23)26-27-22(18-36-31(27)40)25-21-15-9-11-17-24(21)39(29(25)28(26)38)35(34,2)43-33/h5-17,30,33H,18H2,1-4H3,(H,36,40)/t30-,33-,34-,35+/m1/s1
InChI key IIQIEMHSDLLZQA-QZPVEUDVSA-N

安全信息

象形图 GHS08
警示用语: Danger
危险声明 H360FD
预防措施声明 P201 - P202 - P280 - P308 + P313 - P405 - P501
危险分类 Repr. 1B
储存分类代码 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

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