sPLA₂-IIA Inhibitor I-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A highly hydrophobic cyclic pentapeptide that selectively binds and acts as a potent inhibitor of sPLA₂-IIA (human type IIA secreted phospholipase A₂; IC₅₀= 12.8 μM). Shown to effectively block sPLA₂-IIA-induced PGE₂production at 100 nM in human rheumatoid synoviocytes and is non-toxic at doses up to 10 μM. Does not have any significant effect on the activities of porcine sPLA₂-IB,Naja najasPLA₂-IB, orCrotalus durissussPLA₂-IIA even at 10 μM concentration.
A highly hydrophobic cyclic pentapeptide that selectively binds and acts as a potent inhibitor of human type IIA secreted phospholipase A₂(sPLA₂-IIA) (IC₅₀= 12.8 ?M). Reported to effectively block sPLA₂-IIA-induced PGE₂production at 100 nM in human rheumatoid synoviocytes and is non-toxic at doses up to 10 ?M. Does not have any significant effect on the activities of porcine sPLA₂-IB,Naja najasPLA₂-IB, orCrotalus durissussPLA₂-IIA at 10 ?M.

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Primary Target
sPLA2-IIA (human type IIA secreted phospholipase A2
Product does not compete with ATP.
Reversible: no
Target IC₅₀: 12.8 ?M against sPLA2-IIA (human type IIA secreted phospholipase A2
Cell permeable: no

警告

Toxicity: Standard Handling (A)

序列

cyclic(2-NaphthylAla-Leu-Ser-2-NaphthylAla-Arg)?TFA

其他说明

Church, W.B., et al. 2001.J. Biol. Chem.276,33156.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C41H50N8O6· xC2HF3O2
分子量	750.89 (free base basis)

半岛bd体育手机客户端 性质

质量水平	100
测定	≥95% (HPLC)
形式	lyophilized solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze desiccated (hygroscopic)
颜色	white
溶解性	DMSO: 5 mg/mL
运输	ambient
储存温度	?20℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable